Natural Der p 1 屋塵螨過敏原Der p 1
Natural Der p 1 屋塵螨過敏原Der p 1
產品貨號：NA-DP1-1
促銷：
￥8720.00
價格：
￥8720.00
分享到：
250ug
美國Indoor
| Allergen: | nDer p 1 (Dermatophagoides pteronyssinus allergen 1) |
| Unit: | 500μg |
| Source: | D.pteronyssinus culture medium |
| Mol. Wt: | 24 kD |
| Purification: | From mite culture by affinity chromatography. Purity on |
| Concentration: | See package insert. Based on Advanced Protein Assay. (Cytoskeleton Inc., Denver, CO) |
| Formulation: | Preservative-free and carrier-free in phosphate buffered saline, |
| Storage: | Store at -20oC |
| Notes: | (1) Not tested for endotoxin. (2) Similar nDer p 1 preparations have been used in studies to analyze the cysteine protease activity of Der p 1, for T cell proliferation studies and antibody binding. |
| PDB: | 1XKG, 2AS8, 3F5V X-ray crystal structures |
| Product Resources: | Natural Der p 1 Certificate of Analysis |
| Related products: | LTN-DP1-1 LoTox? Natural Der p1 LTR-DP1D-1 LoTox recombinant Der p 1, deglycosyated RP-DP1D-1 Recombinant Der p 1, deglycosylated EL-DP1 Der p 1 ELISA 5H8/4C1 EL-DP1A Der p 1 ELISA 10B9/5H8 MA-5H8-1 5H8 anti Der p 1 MA-4C1-1 4C1 anti Der p 1, Der f 1 MA-10B9-1 10B9 anti Der p 1 BI-4C1-1 Biotinylated 4C1 anti Der p 1, Der f 1 BI-5H8-1 Biotinylated 5H8 anti Der p 1 ST-UAS Universal Allergen Standard |
| For Research Use Only: Not for Diagnostic or Therapeutic Use | |
| References: | |
Lombardero M, Heymann PW, Platts-Mills TAE, Fox JW, Chapman MD. Conformational stability of B cell epitopes on Group 1 and Group II Dermatophagoides spp. Allergens. Effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 1990;144:1353-1360. | |
| Hewitt CRA, Brown AP, Hart BJ, Pritchard DL. A major house dust mite allergen disrupts the Immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. J Exp Med 1995;182:1537-1544. | |
| Schultz O, Laing P, Sewell HF, Shakib F. Der p 1, a major allergen of the house dust mite, proteolytically cleaves the low affinity receptor for human IgE (CD23). Eur J Immunol 1995;25:3191-3194. | |
| King C, Brennan S, Thompson PJ, Stewart GA. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 1998; 161:3645-3651. | |
| Gough L, Schultz O, Sewell HF, Shakib F. The cysteine protease activity of the major house dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody responses. J Exp Med 1999; 190:1897-1901. | |
| Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MD, Robinson C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999; 104:123-133. | |
| Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J Mol Biol, 2009;386:520-530. | |
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